“Assessment of oral health related quality of life among cancer patients using Hindi version of EORTC QLQ OH 15 in western Uttar Pradesh, India- A cross sectional survey ”
oral health related quality of life among cancer patients
Keywords:
Quality of life, Cancer, Oral health, Therapy, EORTC-QLQ-OH-15
Abstract
BACKGROUND: As cancer is predicted to be the leading cause of death and the main obstacle to raising quality of life around the world in the twenty-first century, researchers and policymakers have paid close attention to this disease. Aim: To assess the oral health-related quality of life (HRQL) of cancer patients in relation to their type and therapy of cancer.
METHODS: A cross-sectional survey was carried out among patients being treated in the department of radiotherapy in Aligarh who had been diagnosed with various types of cancer. The Hindi version of EOTRC Core Questionnaires (QLQ-C30 version 3) and Oral Health Module (QLQOH15) were used to evaluate the oral health related quality of life among cancer patients. The QLQ-C30 and QLQOH15 scores were linearly translated to a scale of 0-100, with a higher score denoting either a greater level of functioning or overall QOL or a reduced level of symptoms or difficulties. Through the patients' medical records, demographic and clinical data were also gathered.
RESULTS: The most prevalent kind of malignancy seen was head and neck cancer, which affected 98 (70.1%) individuals. Every patient was undergoing active therapy. Known group comparison showed that elderly patients who underwent more complex treatment had poorer scores in various subscales of Hindi QLQ-OH 15 in comparison to patients in other treatment groups and the results were statistically significant(p≤0.05).
Conclusion: When comparing the QoL of known groups, elderly patients and those who received complicated therapies had lower QoL scores than their counterparts.
References
References
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6. Villa A, Wolff A, Aframian D, Vissink A, Ekström J, Proctor G et al. World Workshop on Oral Medicine VI: a systematic review of medication-induced salivary gland dysfunction: prevalence, diagnosis, and treatment. Clin Oral Investig. 2015;19(7):1563-80. doi: 10.1007/s00784-015-1488-2, PMID 25994331.
7. Hong CH, Napeñas JJ, Hodgson BD, Stokman MA, Mathers-Stauffer V, Elting LS et al. A systematic review of dental disease in patients undergoing cancer therapy. Support Care Cancer. 2010;18(8):1007-21. doi: 10.1007/s00520-010-0873-2, PMID 20449756.
8. Velikova G, Coens C, Efficace F, Greimel E, Groenvold M, Johnson C et al. Health-Related Quality of Life in EORTC clinical trials −30 years of progress from methodological developments to making a real impact on oncology practice. Eur J Cancer Suppl. 2012;10(1):141-9. doi: 10.1016/S1359-6349(12)70023-X.
9. Aaronson NK, Ahmedzai S, Bergman B, Bullinger M, Cull A, Duez NJ et al. The European Organization for Research and Treatment of Cancer QLQ-C30: a quality-of-life instrument for use in international clinical trials in oncology. J Natl Cancer Inst. 1993;85(5):365-76. doi: 10.1093/jnci/85.5.365, PMID 8433390.
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11. Fayers PM, Aaronson NK, Bjordal K et al. The EORTC QLQ-C30 scoring manual. 3rd ed. Brussels: European Organization for Research and Treatment of Cancer; 2001.
12. Kuliś D, Bottomley A, Velikova G et al. EORTC quality of life group translation procedure. 4th ed. Available from: http://eortc.org/app/uploads/sites/2/2018/02/translation_manual_7.pdf. Available from: https://www. [accessed Feb 18] 2021. Vol. 2017; 2017.
13. Chaukar DA, Das AK, Deshpande MS, Pai PS, Pathak KA, Chaturvedi P et al. Quality of life of head and neck cancer patient: validation of the European Organization for Research and Treatment of Cancer QLQ-C30 and European Organization for Research and Treatment of Cancer QLQ-H&N 35 in Indian patients. Indian J Cancer. 2005;42(4):178-84. PMID 16391435.
14. Ferrell BR, Dow KH, Grant M. Measurement of the quality of life in cancer survivors. Qual Life Res. 1995;4(6):523-31. doi: 10.1007/BF00634747, PMID 8556012.
15. Wong HM. Oral complications and management strategies for patients undergoing cancer therapy. ScientificWorldJournal. 2014;2014:581795. doi: 10.1155/2014/581795, PMID 24511293.
16. Sonis ST, Fey EG. Oral complications of cancer therapy. Oncology (Williston Park). 2002;16(5):680-6. PMID 12108892.
17. Sonis ST, Elting LS, Keefe D, Peterson DE, Schubert M, Hauer-Jensen M et al. Perspectives on cancer therapy-induced mucosal injury: pathogenesis, measurement, epidemiology, and consequences for patients. Cancer. 2004;100(9);Suppl:1995-2025. doi: 10.1002/cncr.20162, PMID 15108222.
18. Epstein JB, Murphy BA. Late effects of cancer and cancer therapy on oral health and quality of life. J Mass Dent Soc. 2010;59(3):22-7. PMID 21125933.
19. Epstein JB, Parker IR, Epstein MS, Gupta A, Kutis S, Witkowski DM. A survey of National Cancer Institute‐designated comprehensive cancer centers’ oral health supportive care practices and resources in the USA. Support Care Cancer. 2007;15(4):357-62. doi: 10.1007/s00520-006-0160-4, PMID 17205282.
20. Scully C, Epstein J, Sonis S. Oral mucositis: A challenging complication of radiotherapy, chemotherapy, and radiochemotherapy. Part 2: Diagnosis and management of mucositis. Head Neck. 2004;26(1):77-84. doi: 10.1002/hed.10326, PMID 14724910.
21. Teunissen SC, Wesker W, Kruitwagen C, de Haes HC, Voest EE, de Graeff A. Symptom prevalence in patients with incurable cancer: A systematic review. J Pain Symptom Manag. 2007;34(1):94-104. doi: 10.1016/j.jpainsymman.2006.10.015, PMID 17509812.
22. Yekaninejad MS, Pakpour AH, Tadakamadla J, Kumar S, Mosavi SH, Fridlund B et al. Oral Health-related quality of life in patients with cancer: cultural adaptation and the psychometric testing of the Persian version of EORTC QLQ-OH17. Support Care Cancer. 2015;23(5):1215-24. doi: 10.1007/s00520-014-2468-9, PMID 25312650.
23. Liu J, Gao J, Wu CX et al. Reliability, validity and responsiveness of the Mandarin (Simplified). Chinese version of the EORTC QLQ-OH45 among cancer patients. Eur J Cancer Care (Engl). Chinese version 28(2):e12987; 2019.
24. Kosgallana S, Jayasekara P, Abeysinghe P, Hjermstad M, Lalloo R. Translation and validation of Sinhala version of modified EORTC QLQ-OH15 in oral cancer patients who receive radiotherapy with or without chemotherapy in Sri Lanka. BMC Oral Health. 2022;22(1):359. doi: 10.1186/s12903-022-02392-y, PMID 35986341.
25. Perwitasari DA, Atthobari J, Dwiprahasto I, Hakimi M, Gelderblom H, Putter H et al. Translation and validation of EORTC QLQ-C30 into Indonesian version for cancer patients in Indonesia. Jpn J Clin Oncol. 2011;41(4):519-29. doi: 10.1093/jjco/hyq243, PMID 21266448.
26. Sung H, Ferlay J, Siegel RL, Laversanne M, Soerjomataram I, Jemal A et al. Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 2021;71(3):209-49. doi: 10.3322/caac.21660, PMID 33538338.
27. Hjermstad MJ, Bergenmar M, Fisher SE, Montel S, Nicolatou-Galitis O, Raber-Durlacher J et al. The EORTC QLQ-OH17: A supplementary module to the EORTC QLQ-C30 for assessment of oral health and quality of life in cancer patients. Eur J Cancer. 2012;48(14):2203-11. doi: 10.1016/j.ejca.2012.04.003, PMID 22572480.
28. Nordgren M, Hammerlid E, Bjordal K, Ahlner-Elmqvist M, Boysen M, Jannert M. Quality of life in oral carcinoma: a 5-year prospective study. Head Neck. 2008;30(4):461-70. doi: 10.1002/hed.20735, PMID 18098303.
29. Yan YB, Meng L, Liu ZQ, Xu JB, Liu H, Shen J et al. Quality of life in long-term oral cancer survivors: an 8-year prospective study in China. Oral Surg Oral Med Oral Pathol Oral Radiol. 2017;123(1):67-75. doi: 10.1016/j.oooo.2016.09.006, PMID 27876377.
30. Andreassen R, Jönsson B, Hadler-Olsen E. Oral Health related quality of life in long-term survivors of head and neck cancer compared to a general population from the seventh Tromsø study. BMC Oral Health. 2022;22(1):100. doi: 10.1186/s12903-022-02140-2, PMID 35354441
1. Bray F, Ferlay J, Soerjomataram I, Siegel RL, Torre LA, Jemal A. Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 2018;68(6):394-424. doi: 10.3322/caac.21492, PMID 30207593.
2. Rajpal S, Kumar A, Joe W. Economic burden of cancer in India: evidence from cross-sectional nationally representative household survey, 2014. PLOS ONE. 2018;13(2):e0193320. doi: 10.1371/journal.pone.0193320, PMID 29481563.
3. WHO. World health statistics 2019: monitoring health for the SDGs. Geneva, Switzerland: World Health Organization; 2018 [cited Jun 26 2020]. Available from: https://www.who.int/publications-detail-redirect/9789241565707.
4. Hall WH. Oral complications of cancer therapies. J Neurosurg. 1990;72(5):831-2. doi: 10.3171/jns.1990.72.5.0831, PMID 2324808.
5. Epstein JB, Thariat J, Bensadoun RJ, Barasch A, Murphy BA, Kolnick L et al. Oral complications of cancer and cancer therapy: from cancer treatment to survivorship. CA Cancer J Clin. 2012;62(6):400-22. doi: 10.3322/caac.21157, PMID 22972543.
6. Villa A, Wolff A, Aframian D, Vissink A, Ekström J, Proctor G et al. World Workshop on Oral Medicine VI: a systematic review of medication-induced salivary gland dysfunction: prevalence, diagnosis, and treatment. Clin Oral Investig. 2015;19(7):1563-80. doi: 10.1007/s00784-015-1488-2, PMID 25994331.
7. Hong CH, Napeñas JJ, Hodgson BD, Stokman MA, Mathers-Stauffer V, Elting LS et al. A systematic review of dental disease in patients undergoing cancer therapy. Support Care Cancer. 2010;18(8):1007-21. doi: 10.1007/s00520-010-0873-2, PMID 20449756.
8. Velikova G, Coens C, Efficace F, Greimel E, Groenvold M, Johnson C et al. Health-Related Quality of Life in EORTC clinical trials −30 years of progress from methodological developments to making a real impact on oncology practice. Eur J Cancer Suppl. 2012;10(1):141-9. doi: 10.1016/S1359-6349(12)70023-X.
9. Aaronson NK, Ahmedzai S, Bergman B, Bullinger M, Cull A, Duez NJ et al. The European Organization for Research and Treatment of Cancer QLQ-C30: a quality-of-life instrument for use in international clinical trials in oncology. J Natl Cancer Inst. 1993;85(5):365-76. doi: 10.1093/jnci/85.5.365, PMID 8433390.
10. Hjermstad MJ, Bergenmar M, Bjordal K, Fisher SE, Hofmeister D, Montel S et al. International field testing of the psychometric properties of an EORTC quality of life module for oral health: the EORTC QLQ-OH15. Support Care Cancer. 2016;24(9):3915-24. doi: 10.1007/s00520-016-3216-0, PMID 27113466.
11. Fayers PM, Aaronson NK, Bjordal K et al. The EORTC QLQ-C30 scoring manual. 3rd ed. Brussels: European Organization for Research and Treatment of Cancer; 2001.
12. Kuliś D, Bottomley A, Velikova G et al. EORTC quality of life group translation procedure. 4th ed. Available from: http://eortc.org/app/uploads/sites/2/2018/02/translation_manual_7.pdf. Available from: https://www. [accessed Feb 18] 2021. Vol. 2017; 2017.
13. Chaukar DA, Das AK, Deshpande MS, Pai PS, Pathak KA, Chaturvedi P et al. Quality of life of head and neck cancer patient: validation of the European Organization for Research and Treatment of Cancer QLQ-C30 and European Organization for Research and Treatment of Cancer QLQ-H&N 35 in Indian patients. Indian J Cancer. 2005;42(4):178-84. PMID 16391435.
14. Ferrell BR, Dow KH, Grant M. Measurement of the quality of life in cancer survivors. Qual Life Res. 1995;4(6):523-31. doi: 10.1007/BF00634747, PMID 8556012.
15. Wong HM. Oral complications and management strategies for patients undergoing cancer therapy. ScientificWorldJournal. 2014;2014:581795. doi: 10.1155/2014/581795, PMID 24511293.
16. Sonis ST, Fey EG. Oral complications of cancer therapy. Oncology (Williston Park). 2002;16(5):680-6. PMID 12108892.
17. Sonis ST, Elting LS, Keefe D, Peterson DE, Schubert M, Hauer-Jensen M et al. Perspectives on cancer therapy-induced mucosal injury: pathogenesis, measurement, epidemiology, and consequences for patients. Cancer. 2004;100(9);Suppl:1995-2025. doi: 10.1002/cncr.20162, PMID 15108222.
18. Epstein JB, Murphy BA. Late effects of cancer and cancer therapy on oral health and quality of life. J Mass Dent Soc. 2010;59(3):22-7. PMID 21125933.
19. Epstein JB, Parker IR, Epstein MS, Gupta A, Kutis S, Witkowski DM. A survey of National Cancer Institute‐designated comprehensive cancer centers’ oral health supportive care practices and resources in the USA. Support Care Cancer. 2007;15(4):357-62. doi: 10.1007/s00520-006-0160-4, PMID 17205282.
20. Scully C, Epstein J, Sonis S. Oral mucositis: A challenging complication of radiotherapy, chemotherapy, and radiochemotherapy. Part 2: Diagnosis and management of mucositis. Head Neck. 2004;26(1):77-84. doi: 10.1002/hed.10326, PMID 14724910.
21. Teunissen SC, Wesker W, Kruitwagen C, de Haes HC, Voest EE, de Graeff A. Symptom prevalence in patients with incurable cancer: A systematic review. J Pain Symptom Manag. 2007;34(1):94-104. doi: 10.1016/j.jpainsymman.2006.10.015, PMID 17509812.
22. Yekaninejad MS, Pakpour AH, Tadakamadla J, Kumar S, Mosavi SH, Fridlund B et al. Oral Health-related quality of life in patients with cancer: cultural adaptation and the psychometric testing of the Persian version of EORTC QLQ-OH17. Support Care Cancer. 2015;23(5):1215-24. doi: 10.1007/s00520-014-2468-9, PMID 25312650.
23. Liu J, Gao J, Wu CX et al. Reliability, validity and responsiveness of the Mandarin (Simplified). Chinese version of the EORTC QLQ-OH45 among cancer patients. Eur J Cancer Care (Engl). Chinese version 28(2):e12987; 2019.
24. Kosgallana S, Jayasekara P, Abeysinghe P, Hjermstad M, Lalloo R. Translation and validation of Sinhala version of modified EORTC QLQ-OH15 in oral cancer patients who receive radiotherapy with or without chemotherapy in Sri Lanka. BMC Oral Health. 2022;22(1):359. doi: 10.1186/s12903-022-02392-y, PMID 35986341.
25. Perwitasari DA, Atthobari J, Dwiprahasto I, Hakimi M, Gelderblom H, Putter H et al. Translation and validation of EORTC QLQ-C30 into Indonesian version for cancer patients in Indonesia. Jpn J Clin Oncol. 2011;41(4):519-29. doi: 10.1093/jjco/hyq243, PMID 21266448.
26. Sung H, Ferlay J, Siegel RL, Laversanne M, Soerjomataram I, Jemal A et al. Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 2021;71(3):209-49. doi: 10.3322/caac.21660, PMID 33538338.
27. Hjermstad MJ, Bergenmar M, Fisher SE, Montel S, Nicolatou-Galitis O, Raber-Durlacher J et al. The EORTC QLQ-OH17: A supplementary module to the EORTC QLQ-C30 for assessment of oral health and quality of life in cancer patients. Eur J Cancer. 2012;48(14):2203-11. doi: 10.1016/j.ejca.2012.04.003, PMID 22572480.
28. Nordgren M, Hammerlid E, Bjordal K, Ahlner-Elmqvist M, Boysen M, Jannert M. Quality of life in oral carcinoma: a 5-year prospective study. Head Neck. 2008;30(4):461-70. doi: 10.1002/hed.20735, PMID 18098303.
29. Yan YB, Meng L, Liu ZQ, Xu JB, Liu H, Shen J et al. Quality of life in long-term oral cancer survivors: an 8-year prospective study in China. Oral Surg Oral Med Oral Pathol Oral Radiol. 2017;123(1):67-75. doi: 10.1016/j.oooo.2016.09.006, PMID 27876377.
30. Andreassen R, Jönsson B, Hadler-Olsen E. Oral Health related quality of life in long-term survivors of head and neck cancer compared to a general population from the seventh Tromsø study. BMC Oral Health. 2022;22(1):100. doi: 10.1186/s12903-022-02140-2, PMID 35354441
Published
2023-09-20
How to Cite
Agrawal, N., Gupta, N. D., & Siddiqui, S. A. (2023). “Assessment of oral health related quality of life among cancer patients using Hindi version of EORTC QLQ OH 15 in western Uttar Pradesh, India- A cross sectional survey ”. UNIVERSITY JOURNAL OF DENTAL SCIENCES, 9(4). https://doi.org/10.21276/ujds.2023.9.4.3
Section
Original Research Paper
