Evaluation between the Association of Chronicle of Tooth Extraction with Oral Alveolar Carcinoma: An Observational Clinco-pathological Institutional Assessment

Association of Chronicle of Tooth Extraction with Oral Alveolar Carcinoma

  • Kriti Garg Rama Dental College
  • Vishal Mehrotra
  • Shazia Aslam
  • Jyoti Kiran
  • Akash Srivastava
  • Aaryan Raj Srivastava
Keywords: Alveolus, carcinoma, tooth extraction, tooth mobility, unhealed socket.


malignant tumors of the jaws. One of the most important reasons for the increase in the number of patients diagnosed with oral carcinoma and its association with the high mortality rates is the late detection of the carcinoma. Aims: The aim of the study was to analyse the clinic-pathological relationship between oral alveolus carcinoma and with history of tooth extraction. Materials & Methods: It was an observational, clinic-pathological study.952 Patients aged 30–80 years diagnosed with alveolus carcinoma of the jaws with a history of recent tooth extraction and unhealed socket at the extraction site were included in the study. Demographic, clinical, and disease-related continuous variables were computed for each subject and presented as descriptive statistics including calculation of percentages (% age). Categorical variables were analysed using Chi-square test. Regression analysis was used to identify habits and disease-related variables which can affect the incidence of oral carcinoma. Results: 2655 (33.78%) were diagnosed with alveolus carcinoma while 952(12.11%) patients were associated with a history of dental extraction as a chief complaint. 553(58.08%) patients had developed carcinoma in the proximity of the site of placement of the tobacco, and 431(45.27%) patients underwent extractions as they do not want preventive treatment. Conclusions: The focus of the current study is on early diagnosis and appropriate treatment planning, both of which can affect prognosis. It will also contribute to the enhancement of clinical awareness following tooth extraction.


1. Shah JP, Patel SG, Singh B. Jatin Shah’s head and neck surgery and oncology. 4th ed. Philidelphia, PA: Elsevier Mosby, 2012.
2. Zwetyenga N, Pinsolle J, Rivel J, Majoufre Lefebvre C, Faucher A, Pinsolle V. Primary intraosseous carcinoma of the jaws. Arch Otolaryngol Head Neck Surg 2001; 127:794 7.
3. Mahabaleshwara CH, Lal SS, Kiruba SK, Kulkarni S ,Mohammed BB. Intra alveolar carcinoma diagnosed after teeth extraction - case series and a review. IJADS 2020; 6: 356-58
4. Shenoi R, Devrukhkar V; Chaudhuri, Sharma BK, Sapre SB, Chikhale A. Demographic and clinical profile of oral squamous cell carcinoma patients: a retrospective study. Indian J Cancer. 2012 ;49:21-6. doi: 10.4103/0019-509X.98910
5. Kramer IR, Pindborg JJ, Shear M. The WHO Histological Typing of Odontogenic Tumours. A commentary on the Second Edition. Cancer. 1992;70:2988-94.
doi: 10.1002/1097-0142(19921215)70:12<2988::aid-cncr2820701242>3.0.co;2-v.
6. Zwetyenga N, Pinsolle J, Rivel J, Majoufre Lefebvre C, Faucher A, Pinsolle V. Primary intraosseous carcinoma of the jaws. Arch Otolaryngol Head Neck Surg. 2001; 127:794 7.
7. To EH, Brown JS, Avery BS, Ward-Booth RP. Primary intraosseous carcinoma of the jaws. Three new cases and a review of the literature. Br J Oral Maxillofac Surg. 1991;29:19-25. doi: 10.1016/0266-4356(91)90168-5.
8. Bodner L, Manor E, Shear M, van der Waal I. Primary intraosseous squamous cell carcinoma arising in an odontogenic cyst: A clinicopathologic analysis of 116 reported cases. J Oral Pathol Med. 2011; 40:733-38.
9. Müller S, Waldron CA. Primary intraosseous squamous carcinoma. Report of two cases. Int J Oral Maxillofac Surg. 1991; 20:362-65
10. Saxby PJ, Soutar DS. Intra-oral tumors presenting after dental extraction. Br. Dent. J. 1989;166: 337-38
11. Choi EJ, Zhang X, Kim HJ, Nam W, Cha IH. Prognosis of gingival squamous cell carcinoma diagnosed after invasive procedures. Asian Pac J Cancer Prev. 2011;12:2649-52.
12. Orbak R , Bayraktar C, Kavrut F, Gu¨ndogdu C. Poor oral hygiene and dental trauma as the precipitating factors of squamous cell carcinoma”. Oral Oncology Extra 2005;41: 109-13.
13. Dholam K, Kharade P. Association of History of Tooth Extraction and Carcinoma of Alveolus as Well as Gingiva.EC Dent Sci 2017; 14: 03-06.
14. Singh T, Schenberg M. Delayed diagnosis of oral squamous cell carcinoma following dental treatment. Ann R Coll Surg Engl 2013; 95: 369–73
doi 10.1308/003588413X13629960045599
15. Obuekwe oN, Akpata O, Ojo MA, Madukwe IU, Osaguona AO. Malignant tumours presenting after dental extraction: a case series. East Afr Med J. 2005 ;82:256-9.
doi: 10.4314/eamj.v82i5.9316.
16. Patel SG, Shah JP. TNM staging of cancers of the head and neck: striving for uniformity among diversity. CA Cancer J Clin. 2005 ;55:242-58
doi: 10.3322/canjclin.55.4.242
17. Tandon P, Dadhich A, Saluja H, Bawane S, Sachdeva S. The prevalence of squamous cell carcinoma in different sites of oral cavity at our Rural Health Care Centre in Loni, Maharashtra – a retrospective 10-year study. Contemp Oncol (Pozn) 2017; 21: 178–83.
doi: https://doi.org/10.5114/wo.2017.68628
18. Suei Y, Tanimoto K, Taguchi A, Wada T. Primary intraosseous carcinoma: Review of the literature and diagnostic criteria. J. Oral Maxillofac Surg 1994; 52:580-83.
19. Suzuki K, Shingaki S, Nomura T, Nakajima T. Oral carcinomas detected after extraction of teeth: a clinical and radiographic analysis of 32 cases with special reference to metastasis and survival. Int J Oral Maxillofac Surg 1998; 27: 290–94.
20. Papageorge MB, Lincoln RE. Nonhealing extraction sites: two case reports and a differential diagnosis. J Mass Dent Soc 1994; 43: 20–26.
21. Hong SX, Cha IH, Lee EW, Kim J. Mandibular invasion of the lower gingival carcinoma in the molar region: its clinical implications on the surgical management. Int J Oral Maxillofac Surg 2001; 30: 130–38.
22. Kusukawa J, Suefuji Y, Ryu F, Noguchi R, Iwamoto O, Kameyama T. Dissemination of cancer cells into circulation occurs by incisional biopsy of oral squamous cell carcinoma. J Oral Pathol Med. 2000 ;29:303-7. doi: 10.1034/j.1600-0714.2000.290703.x.
23. Wong TSC, Wiesenfeld D. Oral Cancer. Australian Dental Journal 2018; 63: S91–99.
How to Cite
Garg, K., Mehrotra, V., Aslam , S., Kiran , J., Srivastava, A., & Srivastava , A. R. (2022). Evaluation between the Association of Chronicle of Tooth Extraction with Oral Alveolar Carcinoma: An Observational Clinco-pathological Institutional Assessment . UNIVERSITY JOURNAL OF DENTAL SCIENCES, 8(4). https://doi.org/10.21276//ujds.2022.8.4.8

Most read articles by the same author(s)