Benefit of addition of clonidine to bupivacaine in post operative pain management in mandibular unilateral parasymphysis fracture : A comparative evaluation

Abstract

Introduction: In mandibular trauma  ,mandibular parasymphysis fracture is most common.commomly managed by open reduction and internal fixation(ORIF) under general anesthesia it is important to do adequate analgesia post operatively .

Materials and Methods:  For post operative pain controle we  providing post operative regional anaesthesia of the inferior alveolar nerve block (IANB) ,in this study the vasoconstrictor of choice Clonidine, an α2 adrenergic agonist, has demonstrated potential in improving the duration and quality of analgesia when added to local anaesthetics such as bupivacaine. This study assesses the post-operative results of combining clonidine and bupivacaine in IANB .

Result:  Pain Score in The VAS scores were significantly lower in the clonidine group compared to the control group at all time points . Specifically, at 2 hours post-surgery, score in the clonidine group was 4.73 ± 1.4, compared to 7.47 ± 1.3 in the control group .At 6 hours, the clonidine group still had lower scores (3.1 ± 1.0  vs. 5.6 ± 1.3). At 12 and 24 hours, the clonidine group continued to report significantly lower pain scores. Duration of Analgesia: The mean duration of effective analgesia was significantly longer in the clonidine group as compared to the control group (5.5 ± 1.2 hours) .

Conclusion: The addition of clonidine to bupivacaine in inferior alveolar nerve blocks for mandibular parasymphysis fractures significantly enhances post-operative analgesia.