'Repair the defect' - Emerging topical fluoridated remineralizing agents : A review
Keywords:
Dental caries, Demineralization, Remineralization, Fluoride.
Abstract
A universal public health issue that affects 60% to 90% of people worldwide is dental caries, especially in youngsters. Dental caries is a cyclical event with phases of demineralization and remineralization in addition to being a continuous and unidirectional process of the demineralization of the mineral. Cavitation results from an overbalance in the demineralization process. While remineralization is the process of increasing ion deposition into crystal gaps in demineralized enamel to achieve net mineral gain, it is defined as the supply of calcium and phosphate ions from a source external to the tooth surface. Despite the fact that many other therapies have been tried in recent years to treat early enamel carious lesions, fluorides have emerged as the most popular remineralizing agent due to their superior cariostatic efficacy and affordability. Alternative preparations with additional benefits would be of interest because currently available topical fluorides require patient participation and several treatments over the course of a year.
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Exterkate RAM, Cate JM. Effects of a new titanium fluoride derivative on enamel de and remineralization. Eur J Oral Sci. 2007;115(2):143-147.
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Arifa MK, Ephraim R, Rajamani T. Recent Advances in Dental Hard Tissue Remineralization: A Review of Literature. Int J Clin Pediatr Dent. 2019;12(2):139-144.
Cochrane NJ, Cai F, Huq NL, Burrow MF, Reynolds EC. New approaches to enhanced remineralization of tooth enamel. J Dent Res. 2010;89(11):1187-97.
Soi S, Vinayak V, Singhal A, Roy S. Fluorides and their role in demineralization and remineralization. J Dent Sci Oral Rehab. 2013;19-21.
Pande P, Rana V, Srivastava N, Kaushik N. A compendium on remineralizing agents in dentistry. Int J Appl Dent Sci. 2020;6(1):247-250.
Crystal YO, Niederman R. Evidence-based dentistry update of silver diamine fluoride. Dent Clin North Am. 2019;63(1):45-68.
Nuvvula S, Mallineni SK. Silver diamine fluoride in pediatric dentistry. J South asian Assoc Pediatric dent. 2019;2(2):73-80.
Debangana Choudhury, Nishi Grover, Suleman Abbas Khan, & Saumya Navit. (2021). Silver Diamine Fluoride- The New Black Magic. University journal of dental sciences, 8(1). 113 - 120
Lavanya SSJ, Arangannal P, Jeevarathan J, Aarthi J, Amudha S et al. Nanosilver fluoride- overview. Eur J Mol clin Med. 2020;7(2):6573-80.
Kim JS, Kuk E, Yu KN, Kim JH, Park SJ et al. Antimicrobial effects of silver nanoparticles. Nanomedicine. 2007;3(1):95-101.
Scarpelli BB, Punhagui MF, Hoeppner MG, Almeida RS, Juliani FA, Guiraldo RD, Berger SB. In vitro evaluation of the remineralizing potential and antimicrobial activity of a cariostatic agent with silver nanoparticles. Brazilian Dental Journal. 2017 Dec;28(6):738-43.
Silva E et al, In Vitro morphological, optical and microbiological evaluation of nanosilver fluoride in the remineralization of deciduous teeth enamel. Nanotechnol Rev. 2018;7(6): 509–520.
Freire PL, Stamford TC, Albuquerque AJ, Sampaio FC, Cavalcante HM et al. Action of silver nanoparticles towards biological systems: cytotoxicity evaluation using hen's egg test and inhibition of Streptococcus mutans biofilm formation. Int j of antimicrob agents. 2015;45(2):183-7.
Tirupathi S, Nirmala SV, Rajasekhar S, Nuvvula S. Comparative cariostatic efficacy of a novel Nanosilver fluoride varnish with 38% silver diamine fluoride varnish a double-blind randomized clinical trial. J Clin Exp Dent. 2019;11(2):e105.
Wiegand A, Magalhaes AC, Attin T. Is titamium tetrafluoride (TiF4) effective to prevent caious and erosive lesions? A review of the literature. Oral Health Prev Dent. 2010;8(2):159-64.
Wahengbam P, Tikku AP, Lee WB. Role of titanium tetrafluoride (TiF4) in conservative dentistry: a systemic review. 2011;14(2):98-102.
Shah SG et al. Efficacy of silver diamone fluoride as a topical fluoride agent compared to fluoride varnish and acidulated phosphate fluoride gel: an in vivo study. J of Ped Dent. 2019;2(1):5-12.
Farhadian N, Farhadian M, Borjali M, Ghaderi E. The effect of silver diamine fluoride versus sodium fluoride varnish on the microhardness of demineralized enamel: an in vitro study. A vicenna I Dent Res. 2020;12(1):13-8.
Nozari A, Ajami S, Rafiei A, Niazi E. Impact of nano hydroxyapatite, nano silver fluoride and sodium fluoride varnish on primary teeth enamel remineralization: an in vitro study. J Clin Diagn Res. 2017;11(9):ZC97-ZC100.
Akkyildiz M, Sonmez I. Comparison of remineralizing potential of nano silver fluoride, silver diamine fluoride and sodium fluoride varnish on artificial caries: An in vitro study. Oral Health Prev Dent. 2019;(17):469-77.
Buyukyilmaz T, Tangugsorn V, Ogaard B, Arends J, Ruben J, Rolla G. The effect of titanium tetrafluoride (TiF4) application around orthodontic brackets. Am J Orthod Dentofacial Orthop. 1994;105(3):293-6.
Exterkate RAM, Cate JM. Effects of a new titanium fluoride derivative on enamel de and remineralization. Eur J Oral Sci. 2007;115(2):143-147.
Alaxandria AK, Nassur C, Nobrega CBC, Valenca AMG, Rosalen PL, Maia LC. In situ effect of titanium tetrafluoride varnish on enamel demineralization. Braz Oral Res. 2017;31:e86.
Published
2022-11-19
How to Cite
Singh, M. (2022). ’Repair the defect’ - Emerging topical fluoridated remineralizing agents : A review. UNIVERSITY JOURNAL OF DENTAL SCIENCES, 9(1). https://doi.org/10.21276//ujds.2023.9.1.21
Section
Review Article
