Efficacy of single dose intramuscular methylprednisolone injection into the masseter muscle following the surgical extraction of impacted lower third molars.

  • Sathiyanathan D Senior Lectures, Department of Oral and Maxillofacial Surgery, Madha Dental College and Hospital, Chennai
  • Vivek Nair Assistant Professor, Department of Oral and Maxillofacial Surgery, Bharati Vidyapeeth Dental College and Hospital, Pune
  • Sankar K Professor and Head of Department , Department Of Oral and Maxillofacial Surgery Mahatma Gandhi Postgraduate Institute Of Dental Sciences, Pondicherry.
  • Eswari N Professor, Department Of Oral and Maxillofacial Surgery Mahatma Gandhi Postgraduate Institute Of Dental Sciences, Pondicherry.
  • Anusuya N Resident, Mahatma Gandhi Postgraduate Institute Of Dental Sciences, Pondicherry.
Keywords: Corticosteroids, Impacted third molars, Methylprednisolone, Masseter muscle

Abstract

Aim and Objectives: The clinical study was conducted to evaluate the effect of a single 40 mg dose of methylprednisolone into the masseter muscle via the intrabuccal approach following the surgical extraction of impacted lower third molars under local anesthesia.

Materials and Methods: In this single center, prospective, randomized controlled, double blind study 100 participants were divided into 2 groups. The study group received a single dose of Inj Methylprednisolone 40mg into the masseter muscle via the intrabuccal approach postoperatively, while the control received an I.M placebo drug. The efficacy of this procedure in controlling typical post-operative complications (pain, swelling, and mouth opening) was evaluated.

Results: The patients administered methylprednisolone showed superior results after 2 and 5 days in terms of facial swelling (p < 0.05) and on 5th day after intervention with a p-value of 0.008 in terms on pain.

Conclusion: Results obtained showed that 40 mg of Methylprednisolone can effectively reduce the patient discomfort post operatively after surgical removal of impacted teeth. 

References

References:
1. Penarrocha D, Sa´ez C, Sanchis B, Baga´n S, Gay-Escoda C. Estudio de las complicaciones postoperatorias tras la extraccio´n quiru´rgica de 190 terceros molares mandibulares incluidos. Av Odontoestomatol 2000: 16: 435–441.
2. Holte K, Kehlet H. Perioperative single-dose glucocorticoid administration: pathophysiologic effects and clinical implications. J Am Coll Surg 2002: 195: 694–711.
3. McGrath C, Comfort MB, Lo EC: Changes in life quality following third molar surgery -the immediate postoperative period. Br Dent J 194:265-26.
4. Chukwuneke FN, Oji C, Saheeb DB. A comparative study of the effect of using a rubber drain on post-operative discomfort following lower third molar surgery. Int J Oral Maxillofac Surg. 2008; 37:341-4. DOI: https://doi. org/10.1016/j.ijom.2007.11.016 4.
5. Chopra D, Rehan HS. A randomized, double blind placebo – controlled study comparing the efficacy and safety of Paracetamol, Serratiopeptidase, Ibuprofen and Betamethasone using the dental impaction pain model. Int J Oral Maxillofac Surg. 2009; 38:350-355.
6. Gee J. Therapeutic use of corticosteroids in dentistry. A review. N Y State Dent J 1974: 40: 89–96.
7. Strean P, Horton C. Hydrocortisone in dental practice. Dental digest. 1953; 59:8.
8. Alexander R, Throndson R. A review of perioperative corticosteroid use in dentoalveolar surgery. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2000: 90: 406–415.
9. Lisa Gersema et al: Use of Corticosteroids in Oral surgery J oral Maxillofac surg 1992;50:270-277.
10. Jose Rodrigues Laureano Filho et al: The influence of cryotherapy on reduction of swelling, pain and trismus after third-molar extraction – A preliminary study. J Am Dent Assoc 2005;136:774-778.
11. Antonio Barone et al: A randomized clinical evaluation of Ultrasound Bone surgery versus traditional rotary instruments in lower third molar extraction. J oral Maxillofac Surg. 2010;68:330-336.
12. Marconi Gonzaga Tavares et al: Electro- Acupuncture Efficacy on Pain control after mandibular third molar surgery. Braz dent J. 2007;18(2):158-162.
13. Anil Kumar Danda et al: Influence of primary and secondary closure of surgical wound after impacted mandibular third molar removal on postoperative pain and swelling – A comparative and split mouth study. J Oral Maxillofac Surg 2010; 68:309-312.
14. Roger E Alexander et al: A review of perioperative corticosteroid use in dentoalveolar surgery. Oral surg Oral Med Oral pathol Oral Radiol Endod. 2000;90:406-15.
15. Milles M et al: Reduction of postoperative facial swelling by low-dpse methylprednisolone. J Oral Maxillofac Surg. 1993;51:987.
16. Montgomery M. et al: The use of glucocorticosteroids to lessen the inflammatory sequelae following third molar surgery. J Oral Maxillofac Surg. 1990;48:179-187.
17. Schultze-Mosgau et al: Use of ibuprofen and methylprednisolone for the prevention of pain and swelling after removal of impacted third molars. J Oral Maxillofrac Surg. 1995;53:2-7.
18. Babatunde Olamide Bamgbose et al: Effects of co-administered dexamethasone and diclofenac potassium on pain, swelling and trismus following third molar surgery. Head & Face Medicine 2005, 1:11.
Published
2022-02-11
How to Cite
D, S., Nair, V., K, S., N, E., & N, A. (2022). Efficacy of single dose intramuscular methylprednisolone injection into the masseter muscle following the surgical extraction of impacted lower third molars. UNIVERSITY JOURNAL OF DENTAL SCIENCES, 8(2). https://doi.org/10.21276/ujds.2022.8.2.3