“Reconnoitering the Association of Interleukin-6 with Chronic Periodontitis and Covid-19: An Observational Study
Abstract
Aim: The aim of the present study was to investigate comparatively the systemic levels of interleukin-6 in COVID-19 positive patients with/without chronic periodontitis and recovered COVID-19 patient with/without chronic periodontitis respectively. Methods: Total 200 consecutive confirmed cases were included and categorized equally into four groups- Group1A & Group 1B (COVID-19 positive), Group 2A & Group 2B (COVID-19 recovered),based on periodontal status along with Interleukin-6 levels. Peripheral blood samples were taken and Serum Interleukin-6 concentrations were tested using a highly sensitive (Chemiluminescence immunoassay) CLIA method on admission during hospital stay. Results: There were 50 subjects taken in all study groups. The mean age was 40.80, 38.02, 41.06, 38.98 in Group (1A,1B,2A&2B) respectively and the difference in mean age group was not significant (P>0.05). The mean interleukin-6 level was 26.0752, 1.5306, 4.1290, 0.7514 pg/ml in Group1A, 1B, 2A, 2B respectively and the difference was statistically significant (P-0.0001*). The mean difference in inter-group comparison was seen significant (P<0.05) among group1A vs(1B,2A,2B) & non-significant (P>0.05) among group1Bvs(2A,2B) & group2A vs 2B respectively. Conclusion: Chronic periodontitis must be included in diagnostic work-up to stratify SARS- CoV-2 severity.
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