Rare occurrence of multifocal central gaint cell granuloma of facial bones: A Diagnostic and Therapeutic challenge
Abstract
Introduction: Multifocal central giant cell granulomas of the jaws are infrequent occurrences often linked to systemic diseases or syndromes. Their aggressive clinical behaviour complicates accurate diagnosis. The management of these lesions is tailored to their aggressive nature, with supportive and palliative treatments considered when associated with underlying systemic conditions.
Case presentation: This is a case involving a 23-year-old male presenting with a giant cell lesion in the facial bones, resulting in facial disfigurement without any systemic symptoms and represents a Non Syndromic Multifocal Central giant cell granuloma of facial bones.
Conclusion: Lesions associated with jawbones with a histological feature of osteoclast-like giant cells come under giant cell lesions. Presence of giant cells in many unrelated bone lesions further complicates the diagnosis.
Key-words: Aggressive Central Giant Cell Lesion, Facial Bones, Multifocal
References
2. Munde A, Modi P, Karle R, Wankhede P, Shoeb S. Nonsyndromic synchronous multifocal central giant cell granulomas of the maxillofacial region: report of a case. Journal of Dentistry (Tehran, Iran). 2015 Feb; 12(2):157.
3. Capucha T, Krasovsky A, Abdalla-Aslan R, Ginini JG, Noy D, Emodi O, Rachmiel A, Shilo D. Central giant cell granuloma of the jaws—long-term clinical and radiological outcomes of surgical and pharmacological management. Clinical Oral Investigations. 2024 Mar 7;28(3):200.
4. Butel A, Di Bernardo G, Louvet B. Central giant cell granuloma: a case report. Journal of Oral Medicine and Oral Surgery. 2018 Jan 1; 24(1):24-8.
5. Bilodeau E, Chowdhury K, Collins B. A case of recurrent multifocal central giant cell granulomas. Head and neck pathology. 2009 Jun; 3:174-8.
6. Niedzielska I, Bielecki M, Bąk M, Dziuk B, Niedzielski D. Bony Canal Method of Dexamethasone Injections in Aggressive Form of Central Giant Cell Granuloma—Case Series. Medicina. 2023 Jan 28;59(2):250.
7. Friedrich RE, Rutkowski R, Gosau M. Multiple central giant cell granuloma of the jaws: diagnostic signposts of Noonan syndrome and RASopathy. Oral and Maxillofacial Surgery. 2024 Feb 13:1-7.
8. Ramesh V. “Central giant cell granuloma”–An update. Journal of Oral and Maxillofacial Pathology. 2020 Sep 1; 24(3):413-5.
9. Kaur N, Kohli T, Chhina AK. Central giant cell granuloma: A diagnostic predicament. Journal of Advanced Medical and Dental Sciences Research. 2016;4(1):90.
10. Kang MS, Kim HJ. Multiple synchronous central giant cell granulomas of the maxillofacial region: a case report. Journal of the Korean Society of Radiology. 2010 Jan 1; 62(1):11-5.
