Evaluation of Regenerative Endodontic Procedures in Mature Permanent Teeth with Necrotic Pulp and Periapical Radiolucencies: A clinical study

Abstract

Aim: The aim of this study was to analyze the possibility of regenerative endodontic procedures (REPs) in mature permanent  teeth with necrotic pulps and periapical radiolucencies compared to conventional root canal treatment (CRCT).

Methods: Sixty necrotic mature  teeth having single root canals and periapical radiolucencies were randomized to one of two groups (n=30): REP and CRCT . During a 24-month period, clinical and radiological outcomes were evaluated. For statistical analysis, the unpaired or independent t-test and chi-square tests were utilized (all p<.05).

Results: After a 24-month period of follow-up, 11 teeth in the REP group were declared healed, and 12 teeth showed healing, 15 teeth in the CRCT group were declared healed, and 8 teeth exhibited healing, and difference was not statistically significant (p>.05). At follow-up visits, both groups showed absence and reduction in clinical signs/symptoms, with no significant difference (p>.05). At the end of 12 months, 42.3% of teeth in the REP group responded positively to sensibility tests with a significant difference compared to CRCT group (p<.05).

Conclusion: In the current study, a modified regenerative technique was utilized and according to the findings of this study, REPs may be employed as a potential therapeutic modality for necrotic mature teeth with  periapical radiolucencies.