Journey of Platelet concentrates in Periodontal Regeneration – A review

Tanu Sahney; Shivam Singh; Mondeep Baruah; Christina L. Pachuau

doi:10.21276//ujds.2024.10.2.17

Tanu Sahney Assistant professor, Department of Periodontology, Sardar Patel Post Graduate Institute of Dental and Medical Sciences, Lucknow (U.P.)
Shivam Singh Post Graduate, Department of Periodontology, Sardar Patel Post Graduate Institute of Dental and Medical Sciences, Lucknow (U.P.)
Mondeep Baruah Post Graduate, Department of Periodontology, Sardar Patel Post Graduate Institute of Dental and Medical Sciences, Lucknow (U.P.)
Christina L. Pachuau Post Graduate, Department of Periodontology, Sardar Patel Post Graduate Institute of Dental and Medical Sciences, Lucknow (U.P.)

DOI: https://doi.org/10.21276//ujds.2024.10.2.17

Keywords: Platelet concentrates, Platelet rich fibrin, Concentrated growth factor, Sticky bone, Injectable platelet rich fibrin, sticky bone

Abstract

Platelet concentrates are the derivatives of blood which helps in haemostasis and wound healing after periodontal regenerative procedures and are enriched with growth factors are well-known to boost the healing process and have started to be in trend and utilized clinically in periodontal surgical procedures. These are prepared from the patient’s own blood throughout which the activated platelets become close and form a fibrin matrix scaffold that releases growth factors and cytokines which plays a key role in tissue regeneration; including cell proliferation and differentiation, extracellular matrix synthesis, chemotaxis and angiogenesis. Its autologous nature provides an advantage to the patients as it reduces treatment cost and minimizes the risk of cross-infection. Despite its exclusive application in promoting healing, there is data paucity on the role of platelet concentrates on bone regeneration. Therefore, this review aims to explore the potential bone regenerative effect of platelet concentrates that would be beneficial as one of the alternative options in periodontal regenerative procedures. Even though the application of platelet concentrates has shown promising outcomes, there is a need for further studies to discover the potential of platelet concentrates in bone regeneration.

This review highlights various types of platelet concentrates, and their clinical applications within the treatment of periodontal diseases.