Comparative clinical efficacy of Murraya koenigii gel and chlorhexidine gluconate gel for improvement of oral health
Abstract
Comparative clinical efficacy of Murraya koenigii gel and Chlorhexidine gluconate gel for improvement of oral health
Introduction: Gingivitis is a non-destructive, plaque induced disease that causes inflammation of the gums. Chlorhexidine is regarded as the gold standard agent due to its chemical substantivity and clinical efficacy in chemical plaque control. Nowadays, herbal products are widely substituting synthetic antimicrobials due to their minimal side effects and cost effectiveness. Murraya koenigii (curry leaf) is an easily available green leaf in the Indian subcontinent, known for its antimicrobial, antioxidative, and cytotoxic activity.
Objective: This study was aimed to evaluate the effectiveness of M. koenigii gel in reduction of plaque and gingivitis when compared with commercially available Chlorhexidine (Hexigel) gel.
Materials and Method: This single center, randomized controlled clinical trial was carried out among 40 participants with moderate gingivitis. After scaling, they were divided into two groups: Group I (control) and Group II (Test) [n=20] and were instructed to use Chlorhexidine gel and M. koenigii gel respectively. Clinical parameters (PI & GI) were recorded on baseline and 15 days later. Student’s paired t‑test and independent t-test were used for intra and inter group comparison of clinical parameters.
Results: On intra-group comparison, both the groups showed a statistically significant difference (P = 0.001). Inter-group comparison, showed no statistically significant difference between the two groups. (P > 0.05)
Conclusion: M. koenigii gel is equally effective as Chlorhexidine gel, in treating plaque induced gingivitis.
References
2. Keijser JA, Verkade H, Timmerman MF and Van der Weijden FA. Comparison of 2 commercially available chlorhexidine mouthrinses. Journal of periodontology. 2003; 74: 214-8.
3. Pradeep A, Suke DK, Martande SS, Singh SP, Nagpal K and Naik SB. Triphala, a new herbal mouthwash for the treatment of gingivitis: A randomized controlled clinical trial. Journal of periodontology. 2016; 87: 1352-9.
4. Solís C, Santos A, Nart J and Violant D. 0.2% chlorhexidine mouthwash with an antidiscoloration system versus 0.2% chlorhexidine mouthwash: a prospective clinical comparative study. Journal of periodontology. 2011; 82: 80-5.
5. Sravani K, Suchetha A, Mundinamane D, Bhat D, Chandran N and Rajeshwari H. Plant products in dental and periodontal disease: An overview. Int J Med Dent Sci. 2015; 4: 913-21.
6. Math M and Balasubramaniam P. Curry leaves (Murraya Koenigii spreng) and halitosis. BMJ (South Asia ED). 2003; 19: 211.
7. Silness J and Löe H. Periodontal disease index. Ann Periodontol. 1964; 4: 655-69.
8. Pandita V, Patthi B, Singla A, Singh S, Malhi R and Vashishtha V. Dentistry meets nature-role of herbs in periodontal care: A systematic review. Journal of Indian Association of Public Health Dentistry. 2014; 12: 148.
9. Syam S, Abdul AB, Sukari M, Mohan S, Abdelwahab SI and Wah TS. The growth suppressing effects of girinimbine on HepG2 involve induction of apoptosis and cell cycle arrest. Molecules. 2011; 16: 7155-70.
10. John NR, Gala VC and Sawant CS. Inhibitory effects of plant extracts on multi-species dental biofilm formation in-vitro. Int J Pharm Bio Sci. 2013; 4: 487-95.
11. Sunitha J, Patel S, Madhusudan A and Ravindra S. An in vitro antimicrobial activity of few plant extracts on dental caries microorganisms. Int JA PS BMS. 2012; 3: 294-303.
12. Shekar BC, Nagarajappa R, Jain R, Suma S, Singh R and Thakur R. Minimum inhibitory concentration of the plant extracts' combinations against dental caries and plaque microorganisms: An in vitro study. Journal of Indian Association of Public Health Dentistry. 2016; 14: 456.
13. Varghese A, Babu HM and Kukkera PN. Comparative evaluation of efficacy of Murraya koenigii and chlorhexidine gluconate in the treatment of gingivitis: A randomized controlled clinical trial. Journal of Indian Society of Periodontology. 2018; 22: 427.
