Rare Case of Peripheral Giant Cell Granuloma – A Case Report
Keywords:
REACTIVE, GIANT CELL, PERIPHERAL
Abstract
Peripheral giant cell granuloma is the most common oral giant cell lesion[1]. It normally presents as a soft tissue nodule consisting of multinucleated giant cells in background of mononuclear stromal cells and extravasated red blood cells. This lesion probably does not represent a true neoplasm, but rather may be reactive in nature, believed to be stimulated by local irritation or trauma, but the cause is not certainly known.
Here we reported a case of Peripheral Giant Cell Granuloma at the alveolar mucosa of right maxilla of 46 year old female.
References
1. Tandon PN, Gupta SK, Gupta DS, Jurel SK, Saraswat A. Peripheral giant cell granuloma. Contemp Clin Dent. 2012 Apr;3(Suppl 1):S118-21. doi: 10.4103/0976-237X.95121. PMID: 22629051; PMCID: PMC3354806.[PubMed]
2. Bonetti F, Pelosi G, Martignoni G, Mombello A, Zamboni G, Pea M, et al. Peripheral giant cell granuloma: evidence for osteoclastic differentiation. Oral Surg Oral Med Oral Pathol. 1990;70:471–5. [PubMed] [Google Scholar]
3. Lim L, Gibbins JR. Immunohistochemical and structural evidence of a modified microvasculature in the giant cell granuloma of the jaws. Oral Surg Oral Med Oral Pathol. 1995;79:190–8. [PubMed] [Google Scholar]
4. Mighell AJ, Robinson PA, Hume WJ. PCNA and Ki-67 immunoreactivity in multinucleated cells of giant cell fibroma and peripheral giant cell granuloma. J Oral Pathol Med. 1996;25:193–9. [PubMed] [Google Scholar]
5. Souza PE, Mesquita RA, Gomez RS. Evaluation of p53, PCNA, Ki-67, MDM2 and AgNOR in oral peripheral and central giant cell lesions. Oral Dis. 2000;6:35–9. [PubMed] [Google Scholar]
6. Bo Liu, Shi-Feng Yu, Tie-Jun Li. Multinucleated giant cells in various forms of giant cell containing lesions of the jaws express features of osteoclasts. J Oral Pathol Med. 2003;32:367. [PubMed] [Google Scholar]
7. Carvalho YR, Loyola AM, Gomez RS, Araujo VC. Peripheral giant cell granuloma. An immuno-histochemical and ultrastructural study. Oral Dis. 1995;1:20–5. [PubMed] [Google Scholar]
8.Textbook of Head and Neck Pathology; A volume foundations in Diagnostic pathology; Third edition. 2019, Edited by: Lester D.R.Thompson and justin A. Bishop
9. Brad W. Neville DDS, ... Angela C. Chi DMD, in Color Atlas of Oral and Maxillofacial Diseases, 2019
10. Sharma N, Rana S, Jetley S. Peripheral giant cell granuloma of maxilla. J Indian Soc Periodontol. 2022 Jan-Feb;26(1):75-78. doi: 10.4103/jisp.jisp_624_20. Epub 2021 Sep 27. PMID: 35136321; PMCID: PMC8796777.
2. Bonetti F, Pelosi G, Martignoni G, Mombello A, Zamboni G, Pea M, et al. Peripheral giant cell granuloma: evidence for osteoclastic differentiation. Oral Surg Oral Med Oral Pathol. 1990;70:471–5. [PubMed] [Google Scholar]
3. Lim L, Gibbins JR. Immunohistochemical and structural evidence of a modified microvasculature in the giant cell granuloma of the jaws. Oral Surg Oral Med Oral Pathol. 1995;79:190–8. [PubMed] [Google Scholar]
4. Mighell AJ, Robinson PA, Hume WJ. PCNA and Ki-67 immunoreactivity in multinucleated cells of giant cell fibroma and peripheral giant cell granuloma. J Oral Pathol Med. 1996;25:193–9. [PubMed] [Google Scholar]
5. Souza PE, Mesquita RA, Gomez RS. Evaluation of p53, PCNA, Ki-67, MDM2 and AgNOR in oral peripheral and central giant cell lesions. Oral Dis. 2000;6:35–9. [PubMed] [Google Scholar]
6. Bo Liu, Shi-Feng Yu, Tie-Jun Li. Multinucleated giant cells in various forms of giant cell containing lesions of the jaws express features of osteoclasts. J Oral Pathol Med. 2003;32:367. [PubMed] [Google Scholar]
7. Carvalho YR, Loyola AM, Gomez RS, Araujo VC. Peripheral giant cell granuloma. An immuno-histochemical and ultrastructural study. Oral Dis. 1995;1:20–5. [PubMed] [Google Scholar]
8.Textbook of Head and Neck Pathology; A volume foundations in Diagnostic pathology; Third edition. 2019, Edited by: Lester D.R.Thompson and justin A. Bishop
9. Brad W. Neville DDS, ... Angela C. Chi DMD, in Color Atlas of Oral and Maxillofacial Diseases, 2019
10. Sharma N, Rana S, Jetley S. Peripheral giant cell granuloma of maxilla. J Indian Soc Periodontol. 2022 Jan-Feb;26(1):75-78. doi: 10.4103/jisp.jisp_624_20. Epub 2021 Sep 27. PMID: 35136321; PMCID: PMC8796777.
Published
2024-08-03
How to Cite
DR NITIN JAGGI, DR NIKHIL PUROHIT, PATERIA, D. P., DR MANUSMRITI M. PUROHIT, DR TARUN JESWANI, DR SHUBHANGI PATHAK, DR NIHALANI TANISHQ, & DR ABHISHEK NAKKA. (2024). Rare Case of Peripheral Giant Cell Granuloma – A Case Report. UNIVERSITY JOURNAL OF DENTAL SCIENCES, 10(3). https://doi.org/10.21276/ujds.2024.10.3.9
Section
Case Reports
