Drug-induced Salivary Gland Disorders: A Review Article
Keywords:
Drug-induced, Adverse drug reaction, Salivary gland, Xerostomia, Ptyalism.
Abstract
Every drug can produce unexpected side effects even when used according to the standard dose. Adverse drug reactions can involve any organ and system of the body and are commonly mistaken for signs of underlying disease. The oral cavity can also manifest drug-induced reactions. An optimum salivary function is very crucial in maintaining oral health. The number of drugs and chemicals that can produce adverse reactions in the oral cavity is on the rise. A detailed history of the medication that the patient is taking should be asked as many patients take prescription and non-prescription drugs daily. A clinician should keep themselves updated with the list of offending drugs for proper management of these drug-induced lesions. This will help them in identifying the toxic and unwanted effects of the drugs that can be easily mistaken for symptoms of a common disease.
References
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3. Yuan A, Woo SB. Adverse drug events in the oral cavity. Oral Surg Oral Med Oral Pathol Oral Radiol2015;119:35-47.
4. Lazarou J, Pomeranz BH, Corey PN. Incidence of adverse drug reactions in hospitalized patients: Meta-analysis of Prospective Studies. JAMA 1998;279:1200-1205.
5. Shinkai RS, Hatch JP, Schmidt CB, Sartori EA. Exposure to the oral side effects of medication in a community-based sample.Spec Care Dentist 2006,26(3):116-20.
6. The functions of human saliva: A review sponsored by the World Workshop on Oral Medicine VI Dawes C, Pedersen AML, Villa A, Ekstrom J, Proctor GB, VissinkA, Aframian D, McGowan R, Aliko A, Narayana N, SiaYW, Joshi RK, Jensen SB, Kerr AR, Wolff A. Archives of oral biology 2015;60:863-874.
7.Abdollahi M, Rahimi R, Radfar M. Current Opinion on Drug-induced Oral Reactions: A Comprehensive Review. J Contemp Dent PractMarch 2008;9(3):1-15.
8.Tredwin CJ, Scully C, Bagan-Sebastian JV. Drug-induced disorders of teeth. J Dent Res 2005;84(7):596-602.
9. Laurencin-Dalicieux S, Souche, B, Cousty S.Drug-Induced Salivary Gland Disturbances. Springer Nature Switzerland AG 2021;81-89.
10. C. Scully and J.-V. Bagan. Adverse Drug Reactions in the Orofacial Region. Crit Rev Oral Biol Med 2004;15(4):221-239.
11. Scully C. Drug effects on salivary glands: dry mouth. Oral Dis 2003;9:165-176.
12. Chakrabarti S, Mishra A, Agarwal JP, Garg A, Nair D, Chaturvedi P. Acute toxicities of adjuvant treatment in patients of oral squamous cell carcinoma with and without submucous fibrosis: A retrospective audit. J Can Res Ther 2016;12:932-7.
13. Shetty SR, Bhowmick S, Castelino R, Babu S. Drug-induced xerostomia in elderly individuals: An institutional study. Contemp Clin Dent 2012;3:173-5.
14. Tan ECK,Lexomboon D,Sandborgh-Englund G, Haasum Y, Johnell K. Medications That Cause Dry Mouth As an Adverse Effect in Older People: A Systematic Review and Metaanalysis. J Am Geriatr Soc 2018;66:76–84.
15. Wolff A,Joshi RK, Ekstrom J, Aframian D, Pedersen AML, Proctor G, Narayana N, Villa A, Sia YW, Aliko A, McGowan R, Kerr AR, Jensen SB,Vissink A, Dawes C. A Guide to Medications Inducing Salivary Gland Dysfunction, Xerostomia, and Subjective Sialorrhea: A Systematic Review Sponsored by the World Workshop on Oral Medicine VI. Drugs R D 2017;17:1–28. DOI 10.1007/s40268-016-0153-9.
16.Porter SR, Scully C, Hegarty AM. An update of the etiology and management of xerostomia. Oral Surg Oral Med Oral Pathol Oral RadiolEndod 2004;97(1):28-46.
17. Gil-Montoya JA, Silvestre FJ, Barrios R, Silvestre-Rangil J. Treatment of xerostomia and hyposalivation in the elderly: A systematic review. Med Oral Patol OralCir Bucal. 2016 May1;21(3):e355-66.
18.Seymour RA, Meechan JG, Walton JG. Adverse drug reactions in dentistry. Second edition. Oxford University Press Inc., New York; 1996.
19. Boyce HW, Bakheet MR. Sialorrhea: A review of a vexing, often unrecognized sign of oropharyngeal and esophageal disease. J Clin Gastroenterol 2005;39(2):89-97.
20. Neville, Dam, Allen, Bouquet. Oral and maxillofacial pathology. Third edition. Reed Elsevier India Private Limited, India; 2009.
21.Hadjibabaie M, Rastkari N, Rezaie A, Abdollahi M. The adverse drug reaction in the gastrointestinal tract: An overview. Int J Pharmacol 2005;1(1):1-8.
Published
2023-09-21
How to Cite
Garg, A., Apurva Garg, Urvashi Tomar, Bhuvnesh Airen, Kundendu Arya Bishan, & Himanshu Singh. (2023). Drug-induced Salivary Gland Disorders: A Review Article. UNIVERSITY JOURNAL OF DENTAL SCIENCES, 9(4). https://doi.org/10.21276/ujds.2023.9.4.21
Section
Oral Pathology
